Lokale infectie
- Periorbital cellulitis
- Blepharochalasis – An immune-mediated inflammation of the eyelid
Improper functioning of the tear glands
Allergies – leaks in the subcutaneous capillary beds
Interne ziekten
- Hypothyroidism and Hyperthyroidism
- Nephrotic syndrome
- dermatomyositis
Veneuze obstructie
- Cavernous sinus syndrome
- Superior vena cava obstruction
Infectie
- Mononucleosis
- Chagas disease: Romaña's sign: unilateral, painless, periorbital edema
- Trichinosis
Fluid retention
- pregnancy
- hormonal variations with menstruation
Gedrag
- sleep deprivation
- much dietary sodium
- alcohol and tobacco use
- Crying – The salt in tears may cause fluid retention in the eye area
Normal aging

Orbitale tekenen of vergroting traanklieren
- orbitale tekenen: proptose, verplaatsing oog, atrofie opticus, bewegingsbeperking oog, chemosis, ptosis
- CRP
- MRI orbita: massa
- overweeg biopt
Unilateraal
- traumatisch, conjunctivitis, hordoleum?
--> nee: MRI
Bilateraal
- acuut: trauma, contact allergie, conjunctivitis?
- chronisch: MRI
- LAB: TSH, kreat/alb/eiwit urine, BB, leverproeven/HCV-serologie, systeemziekte: CRP/BSE/ANA/ACE/ANCA/lysozyme, medicatie, VDRL, FTA-AB
- biopt